Capsaicin-Treated Rats Caudalis Nociceptive Neurons in Normal and Neonatally Effects of GABA Receptor Antagonist on Trigeminal
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Effects of GABA receptor antagonist on trigeminal caudalis nociceptive neurons in normal and neonatally capsaicin-treated rats.
We have recently demonstrated that significant increases in cutaneous mechanoreceptive field (RF) size and spontaneous activity occur in nociceptive neurons of trigeminal subnucleus caudalis (Vc, the medullary dorsal horn) of adult rats depleted of C-fiber afferents by neonatal treatment with capsaicin. These neuronal changes in capsaicin-treated (CAP) rats are suggestive of central neuroplasti...
متن کاملNMDA receptor involvement in neuroplastic changes induced by neonatal capsaicin treatment in trigeminal nociceptive neurons.
NMDA receptor involvement in neuroplastic changes induced by neonatal capsaicin treatment in trigeminal nociceptive neurons. J. Neurophysiol. 78: 2799-2803, 1997. This study examines whether 1) the neonatal loss of C-fiber afferents results in neuroplastic changes in the mechanoreceptive field (RF) properties and spontaneous activity of nociceptive neurons in trigeminal subnucleus caudalis (med...
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Objective.—To explore whether pharmacological stimulation of the 5-hydroxytryptamine7 (5-HT7) receptor modulates Fos-like immunoreactivity in the trigeminal nucleus caudalis of rats. Background.—The serotonin 5-HT7 receptor was proposed to be involved in migraine pathogenesis and evidence suggests it plays a role in peripheral nociception and hyperalgesia through an action on sensory afferent n...
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BACKGROUND In order to evaluate mechanisms that may underlie the sensitization of trigeminal spinal subnucleus caudalis (Vc; the medullary dorsal horn) and upper cervical spinal cord (C1-C2) nociceptive neurons to heat, cold and mechanical stimuli following topical capsaicin treatment of the facial skin, nocifensive behaviors as well as phosphorylation of extracellular regulated-kinase (pERK) i...
متن کاملRAPID COMMUNICATION NMDA Receptor Involvement in Neuroplastic Changes Induced By Neonatal Capsaicin Treatment in Trigeminal Nociceptive Neurons
Chiang, Chen Yu, James W. Hu, and Barry J. Sessle. NMDA nociceptive neurons in trigeminal (V) subnucleus caudalis receptor involvement in neuroplastic changes induced by neonatal (medullary dorsal horn) of adult rats and 2) that NMDA capsaicin treatment in trigeminal nociceptive neurons. J. Neuroreceptor mechanisms are involved in these neuroplastic physiol. 78: 2799–2803, 1997. This study exam...
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تاریخ انتشار 1999